ABSTRACT
Objective: To determine histological changes in my epithelial cells and ducts in breast tissue after oral administration of Aspirin
Study Design: Experimental Study
Place and Duration: The study was conducted at Islamic International Medical College, Rawalpindi, during 1st August 2011- 31st October 2011
Methodology: Twenty adult male rabbits were obtained from national institute of health. Ten rabbits were included in experimental group and 10 were used as their controls. The experimental group was given 500 mg Aspirin / 10 ml of water/day for 30 days through infant feeding tube. Day 0 was taken as day of stat of experiment. After 30 days rabbits were sacrificed and breast tissue was taken
Results: The number of myoepithelial cells was significantly more as compared to control group. The interlobular connective tissue around the ducts and alveoli was loosely arranged and cellular, whereas that surrounding the larger ducts and lobes [interlobular connective tissue] was variably dense and contained much adipose tissue
Conclusion: Aspirin influences normal histology of breast and myoepithelial cells respond to oral intake of aspirin
ABSTRACT
To study the five years survival rate after resection for gastric carcinoma. Fifty six patients with gastric carcinoma in different stages were followed up for 5 years after gastric surgery to see recurrence, complications and survival rate. Of the 56 patients, 6 underwent total gastrectomy, 50 partial gastrectomy, 7 Billroth I and 43 modified Dl resection with Billroth II reconstruction. Six patients were alive at the end of 5th year, 3 with early gastric carcinoma and 3 with locally advanced carcinoma. Mortality was 17 patients in the first year, 10 in second year, 8 in third year, 3 in fourth year and 1 in the fifth year. Gastric carcinoma carries a bad prognosis. The 5-year survival rate in our series was 1.3%. Efforts should be made to diagnose and treat these patients at an early stage